Albumin

Albumin

Let’s learn together what is albumin and what is its function?

1. Albumin in only synthesized in liver
2. Albumin = 40 to 60 % of total proteins
3. Carrier protein for :
• Bilirubin •Calcium
• Hormones ( as T3, progesterone ,..)
1. low levels leads to edema
2. Maintain osmotic pressure
3. Half life is 17 day

 Clinical significance:

Useful as an indicator of hepatocellular injury

Hyper albuminemia :
– Dehydration ( in this case, Globulin are also increase
+ A/G is normal
+ Hyperpyoteinrmia)

Hypo albuminemia:

1-Decrease production :
• Starvation
• Sever malabsorption
• Chronic hepatic disease
• Neoplastic disease

2-Abnormal loss of Albumin:
• Renal disease
• Hemorrhage, protein loosing enteropathy

3- Dilution :

due to excessive administration of fluids ( In case of fluid therapy)